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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHighly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine (ES285) from a Morita-Baylis-Hillman adductpt_BR
dc.contributor.authorAmarante, GWpt_BR
dc.contributor.authorCavallaro, Mpt_BR
dc.contributor.authorCoelho, Fpt_BR
unicamp.author.emailcoelho@iqm.unicamp.brpt_BR
unicamp.authorAmarante, Giovanni W. Cavallaro, Mayra Coelho, Fernando Univ Estadual Campinas, Inst Chem, Dept Organ Chem, Lab Synth Nat Prod & Drugs, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subject.wosElectrospray-ionization Masspt_BR
dc.subject.wosMarine Natural-productspt_BR
dc.subject.wosStereoselective-synthesispt_BR
dc.subject.wosMechanismpt_BR
dc.subject.wosSpectrometrypt_BR
dc.subject.wosSpisulosinept_BR
dc.subject.wosCatalysispt_BR
dc.subject.wosChemistrypt_BR
dc.subject.wosReagentpt_BR
dc.subject.wosRoutept_BR
dc.description.abstractWe disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was subsequently used as substrate in a highly diastereoselective reductive amination reaction. (C) 2010 Elsevier Ltd. All rights reserved.pt
dc.relation.ispartofTetrahedron Letterspt_BR
dc.relation.ispartofabbreviationTetrahedron Lett.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherPergamon-elsevier Science Ltdpt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculationMAY 12pt_BR
dc.identifier.citationTetrahedron Letters. Pergamon-elsevier Science Ltd, v. 51, n. 19, n. 2597, n. 2599, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume51pt_BR
dc.description.issuenumber19pt_BR
dc.description.firstpage2597pt_BR
dc.description.lastpage2599pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0040-4039pt_BR
dc.identifier.wosidWOS:000277696000008pt_BR
dc.identifier.doi10.1016/j.tetlet.2010.02.169pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2014-11-18T11:15:34Z
dc.date.available2015-11-26T16:54:26Z-
dc.date.accessioned2014-11-18T11:15:34Z
dc.date.accessioned2015-11-26T16:54:26Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T11:15:34Z (GMT). No. of bitstreams: 1 WOS000277696000008.pdf: 291621 bytes, checksum: e271d57426ee8bf4ca2453db34451f5c (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:54:26Z (GMT). No. of bitstreams: 2 WOS000277696000008.pdf: 291621 bytes, checksum: e271d57426ee8bf4ca2453db34451f5c (MD5) WOS000277696000008.pdf.txt: 15370 bytes, checksum: c3d0d886dda545116fc3c0a4160556d4 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68408pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/68408
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68408-
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