Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/68408
Type: Artigo de periódico
Title: Highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine (ES285) from a Morita-Baylis-Hillman adduct
Author: Amarante, GW
Cavallaro, M
Coelho, F
Abstract: We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was subsequently used as substrate in a highly diastereoselective reductive amination reaction. (C) 2010 Elsevier Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2010.02.169
Date Issue: 2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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