Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine (ES285) from a Morita-Baylis-Hillman adduct|
|Abstract:||We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was subsequently used as substrate in a highly diastereoselective reductive amination reaction. (C) 2010 Elsevier Ltd. All rights reserved.|
|Editor:||Pergamon-elsevier Science Ltd|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.