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Type: Artigo de periódico
Title: High-density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during the acute phase of myocardial infarction: A study by euglycemic hyperinsulinemic clamp
Author: Carvalho, LSF
Martins, NV
Moura, FA
Cintra, RMR
Almeida, OLR
Silva, JCQE
Sposito, AC
Abstract: BACKGROUND: The decrease of insulin sensitivity (IS) during myocardial infarction (MI) is strongly associated with increased morbidity and mortality. Recent data suggest that in individuals under stable conditions, high-density lipoprotein (HDL) may improve IS. To date, the role of HDL in the modulation of IS in acute metabolic stress conditions such as MI remains unknown. OBJECTIVE: To explore the association between plasma HDL-C and the change in IS during the acute phase of MI. METHODS: Consecutive nondiabetic patients with ST-segment elevation MI (n = 22) underwent direct measurement of IS through the euglycemic hyperinsulinemic clamp on the first morning and on the fifth day after onset of MI. Patients were grouped according to HDL-C levels at admission above and below the median value (35 mg/dL). RESULTS: At admission, there was no significant difference in baseline IS index, clinical, anthropometric, or treatment characteristics between low and high HDL groups. Between admission and fifth day, there was a decrease of 8% in IS index in the low HDL group and an 11% increase in the high HDL group (P = .001 for intragroup and P = .012 for intergroup difference). This difference remained significant after we controlled for the sex, age, waist circumference, triglycerides, baseline IS index, and statin dose during hospitalization. CONCLUSION: This is the first study to provide evidence that plasma levels of HDL-C are strongly associated with the recovery rate of IS during the acute phase of MI. (C) 2013 National Lipid Association. All rights reserved.
Country: EUA
Editor: Elsevier Science Inc
Citation: Journal Of Clinical Lipidology. Elsevier Science Inc, v. 7, n. 1, n. 24, n. 28, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.jacl.2012.10.003
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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