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Type: Artigo de periódico
Title: High prevalence of GB virus C in Brazil and molecular evidence for intrafamilial transmission
Author: Pinho, JRR
Zanotto, PMDA
Ferreira, JLP
Sumita, LM
Carrilho, FJ
da Silva, LC
Capacci, ML
Silva, AO
Guz, B
Goncalves, FL
Goncalves, NSL
Buck, GA
Meyers, GA
Bernardini, AP
Abstract: The prevalence of GB virus C (GBV-C) in candidate Brazilian blood donors with normal and elevated alanine aminotransferase levels was found to be 5.2% (5 of 95) and 6.5% (5 of 76), respectively. Among Brazilian patients, GBV-C was Found in 9.5% (13 of 137) of cases of hepatitis not caused by hepatitis A,virus (HAV), HBV, HCV, HDV, or HEV (non-A-E hepatitis) and in 18.2% (8 of 44) of individuals infected with HCV. Molecular characterization of GBV-C by partial sequencing of the NS3 region showed clustering between members of a single family, implying intrafamilial transmission. In conclusion, these results together suggest that contagion mechanisms which facilitate intrafamiliar transmission of GBV-C may partially explain the high prevalence of viremic carriers worldwide.
Country: EUA
Editor: Amer Soc Microbiology
Citation: Journal Of Clinical Microbiology. Amer Soc Microbiology, v. 37, n. 5, n. 1634, n. 1637, 1999.
Rights: aberto
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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