Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/68224
Type: Artigo de periódico
Title: HEMATOLOGICAL ABNORMALITIES IN PATIENTS CHRONICALLY EXPOSED TO BENZENE - AN UPDATE
Author: RUIZ, MA
VASSALLO, J
DESOUZA, CA
Abstract: A study was carried out into the hematological abnormabilities of peripheral blood bone marrow in patients chronically exposed to benzene. The metabolic biotransformation and the mechanisms involved in toxicity are described. Hematological data are described and discussed. Macrocytosis and lymphopenia are the earlieste hematological signs of benzene toxicity. Bone marrow abnormabilities are demostrated by the complementary methods of cytology and histology. Global hypocellularity was mainly due to the granulocytic series. Mastocytosis, eosinophilia and magakariocytic abnormalities are also presented. Inflammatory abnormalities and signs of dismyelopoiese could also be observed. The importance of peripheral blood abnormalities and the need for a critical approach to this important public health problem are emphasized.
Subject: BENZENE
POISONING
HEMATOLOGIC DISEASES
CHEMICALLY INDUCED
OCCUPATIONAL EXPOSURE
Country: Brasil
Editor: Revista De Saude Publica
Rights: aberto
Identifier DOI: 10.1590/S0034-89101993000200011
Date Issue: 1993
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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