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Type: Artigo
Title: Expressão tumoral da glutationa S-transferase Pi e sobrevida global e livre de doença em mulheres com carcinoma de mama
Title Alternative: Glutathione S-transferase Pi expression in invasive breast cancer and its relation with the clinical outcome
Author: Schenka, N.G.M.
Schenka, A.A.
Franco, R.L.
Rezende, L.F.
Gurgel, M.S.C.
Abstract: a glutationa S-transferase (GST) é um sistema enzimático localizado no citosol celular e é responsável pela eliminação de toxinas. Estudos realizados in vitro mostraram que a presença deste sistema nas células do carcinoma de mama pode promover a eliminação do quimioterápico, levando assim à diminuição da eficácia desta modalidade terapêutica em mulheres com carcinoma de mama que expressam tal sistema enzimático em suas células. O presente estudo teve como objetivo avaliar a associação entre a expressão da enzima GST Pi em células tumorais e a sobrevida global e livre de doença em mulheres com carcinoma de mama submetidas ao tratamento quimioterápico
metadata.dc.description.abstractalternative: Glutathione S-transferase (GST) is a cytosolic enzymatic system involved in cellular detoxifying process. In vitro studies have shown that the presence of this enzymatic system in breast carcinoma cells can accelerate the elimination of drugs commonly used in chemotherapy, thereby decreasing its efficacy The aim of the present study was to evaluate the association between GST Pi expression by breast carcinoma cells and disease-free and overall survival. Methods: Ninety-five female patients with invasive breast carcinoma submitted to surgical treatment and adjuvant chemotherapy from January 1995 to June, 1997 and followed until August, 2006 were evaluated. The expression of GST Pi in breast carcinoma cells, determined by immunohistochemistry, was correlated with several clinical and pathological parameters of prognostic significance. Results: There were 36 (37.9%) GST Pi-positive cases. GST Pi immunoexpression was not significantly correlated with patient's age, histological tumor type, clinical stage, hormone receptor status and survival. On the other hand, GST Pi positivity showed a significant correlation with a lower histological grade/C-erb-B2 negative breast carcinoma phenotype. Conclusion: The findings suggest that GST Pi expression does not constitute a satisfactory prognostic factor in breast cancer
Subject: Neoplasias da mama
Glutationa transferase
Country: Grécia
Editor: Zerbinis Medical
Citation: Journal Of Buon. Zerbinis Medical Publ, v. 17, n. 2, n. 259, n. 264, 2012.
Rights: fechado
Identifier DOI: 10.1590/S0100-72032009000200009
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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