Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/68115
Type: Artigo de periódico
Title: Glutathione peroxidase, reduced glutathione, superoxide dismutase and catalase in red cells of patients with hairy cell leukemia
Author: Arruda, VR
Salles, TSI
Costa, FF
Saad, STO
Abstract: Red cell antioxidant enzymes have been recently studied in malignant lymphomas and the results are controversial. Hairy cell leukemia is a rare chronic lymphoproliferative disorder originating probably in a pluripotent stem cell. In the present study, glutathione peroxidase (Gpx), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase were measured in a homogenous group of patients with untreated hairy cell leukemia and normal controls. Glutathione peroxidase, catalase and SOD activities were significantly lower in patients than in normals. GSH was not significantly different in patients compared to controls. There was no correlation between Gpx, GSH, SOD, and catalase and hemoglobin; reticulocytes, leukocytes, hairy cells, platelets number or splenomegaly. Taken together these data suggest a decreased activity of red cell antioxidant enzymes in hairy cell leukemia and support a pluripotent stem cell defect of these abnormalities.
Subject: hairy cell leukemia
antioxidant system
catalase
glutathione
superoxide dismutase
Country: Eslováquia
Editor: Slovak Academic Press Ltd
Rights: fechado
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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