Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/68109
Type: Artigo de periódico
Title: GLUCOSE-INDUCED INSULIN RELEASE IN BETA-THALASSEMIA HETEROZYGOTES
Author: SAAD, STO
SAAD, MJA
Abstract: The human-beta-globin gene cluster and the insulin gene have been assigned to the short arm of chromosome 11 with evidence for linkage (Lebo et al., 1983). In order to investigate if heterozigosity for beta-thalassemia (beta-thal) is linked to an abnormality in insulin secretion, an intravenous glucose tolerance test (IVGTT) was performed on nine beta-thal patients and on 15 healthy subjects. No significant differences were observed between the mean plasma glucose levels of the patients with beta-thal and those of the control group at any time of the IVGTT, and the glucose disappearance rate was similar in the two groups. Serum insulin levels before and after glucose infusion in patients with beta-thal were not significantly different from normals. All indexes of first phase glucose induced insulin release were also similar in the two groups. Previous reports have demonstrated that in sickle cell anemia and associated with the sickle cell trait there is abnormal insulin secretion. However, the results of the IVGTT in the present study suggest that there is no alteration in insulin release in beta-thal patients, possibly because the decreased insulin secretion is an independent genetic abnormality in linkage disequilibrium with the B(s) gene but not with beta-thal genes.
Country: Brasil
Editor: Soc Brasil Genetica
Rights: aberto
Date Issue: 1991
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.