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|Type:||Artigo de periódico|
|Title:||GLUCOSE-INDUCED INSULIN RELEASE IN BETA-THALASSEMIA HETEROZYGOTES|
|Abstract:||The human-beta-globin gene cluster and the insulin gene have been assigned to the short arm of chromosome 11 with evidence for linkage (Lebo et al., 1983). In order to investigate if heterozigosity for beta-thalassemia (beta-thal) is linked to an abnormality in insulin secretion, an intravenous glucose tolerance test (IVGTT) was performed on nine beta-thal patients and on 15 healthy subjects. No significant differences were observed between the mean plasma glucose levels of the patients with beta-thal and those of the control group at any time of the IVGTT, and the glucose disappearance rate was similar in the two groups. Serum insulin levels before and after glucose infusion in patients with beta-thal were not significantly different from normals. All indexes of first phase glucose induced insulin release were also similar in the two groups. Previous reports have demonstrated that in sickle cell anemia and associated with the sickle cell trait there is abnormal insulin secretion. However, the results of the IVGTT in the present study suggest that there is no alteration in insulin release in beta-thal patients, possibly because the decreased insulin secretion is an independent genetic abnormality in linkage disequilibrium with the B(s) gene but not with beta-thal genes.|
|Editor:||Soc Brasil Genetica|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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