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Type: Artigo de periódico
Title: Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with beta-hydroxy-beta-methylbutyrate in rats
Author: Nunes, EA
Goncalves-Neto, LM
Ferreira, FBD
dos Santos, C
Fernandes, LC
Boschero, AC
Calder, PC
Rafacho, A
Abstract: Glucocorticoid (GC) excess alters glucose homeostasis and promotes modifications in murinometric and anthropometric parameters in rodents and humans, respectively. beta-hydroxy-beta-methylbutyrate (HMB), a leucine metabolite, has been proposed as a nutritional strategy for preventing muscle wasting, but few data regarding its effects on glucose homeostasis are available. Here, we analyzed whether the effects of GC excess on glucose homeostasis may be attenuated or exacerbated by the concomitant ingestion of HMB. Adult Wistar rats (90-days-old) were assigned to four groups: (1) vehicle treated (Ctl), (2) dexamethasone (DEX) treated (Dex), (3) HMB treated (Hmb), and (4) DEX plus HMB treated (DexHmb). Dex groups received DEX (1 body weight (BW)(-1), intraperitoneal) for 5 consecutive days. HMB groups ingested HMB (320 BW-1, oral gavage) for the same 5 days. HMB ingestion did not attenuate the effects of DEX on food intake and body weight loss, changes in masses of several organs, insulin resistance, and glucose intolerance (p > 0.05). In fact, in DexHmb rats, there was increased fasting glycemia and exacerbated glucose intolerance with the main effect attributed to DEX treatment (p < 0.05). HMB exerted no attenuating effect on plasma triacylglycerol levels from DexHmb rats, but it seems to attenuate the lipolysis induced by beta-adrenergic stimulation (20 mu mol.L-1 isoproterenol) in fragments of retroperitoneal adipose tissue from DexHmb rats. Therefore, HMB does not attenuate the diabetogenic characteristics of GC excess. In fact, the data suggest that HMB may exacerbate GC-induced glucose intolerance.
Subject: dexamethasone
glucose tolerance
beta-hydroxy-beta-methylbutyrate (HMB)
insulin sensitivity
Country: Canadá
Editor: Canadian Science Publishing, Nrc Research Press
Citation: Applied Physiology Nutrition And Metabolism-physiologie Appliquee Nutrition Et Metabolisme. Canadian Science Publishing, Nrc Research Press, v. 38, n. 11, n. 1137, n. 1146, 2013.
Rights: fechado
Identifier DOI: 10.1139/apnm-2012-0456
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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