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Type: Artigo de periódico
Title: Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion
Author: Scorisa, JM
Zanon, RG
Freria, CM
de Oliveira, ALR
Abstract: Avulsion of ventral roots induces degeneration of most axotomized motoneurons. At present there are no effective strategies to prevent such neuronal loss and to preserve the affected spinal circuits. Interestingly, changes in the spinal cord network also occur during the course of the experimental model of multiple sclerosis (experimental autoimmune encephalomyelitis-EAE). Glatiramer acetate (GA) significantly reduces the seriousness of the symptoms during the exacerbation of EAE. However, little is known about its effects on motoneurons. In the present study, we investigated whether GA has an influence on synapse plasticity and glial reaction after ventral root avulsion (VRA). Lewis rats were subjected to the avulsion of lumbar ventral roots and treated with GA. The animals were sacrificed after 14 days of treatment and the spinal cords processed for immunohistochemistry. A correlation between the synaptic changes and glial activation was obtained by performing immunolabeling against synaptophysin, GFAP and Iba-1. GA treatment preserved synaptophysin labeling, and significantly reduced the glial reaction in the area surrounding the axotomized motoneurons. After ventral root avulsion, GA treatment was also neuroprotective. The present results indicate that the immunomodulator GA has an influence on the stability of nerve terminals in the spinal cord, which may in turn contribute to future treatment strategies after proximal lesions to spinal motoneurons. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Subject: Ventral root avulsion
Spinal cord
Synapse elimination
Glatiramer acetate
Country: Irlanda
Editor: Elsevier Ireland Ltd
Citation: Neuroscience Letters. Elsevier Ireland Ltd, v. 451, n. 1, n. 34, n. 39, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.neulet.2008.12.017
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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