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Type: Artigo de periódico
Title: Genomic structure and regulation of mitochondrial uncoupling protein genes in mammals and plants
Author: Nogueira, FTS
Borecky, J
Vercesi, AE
Arruda, P
Abstract: Uncoupling mitochondrial proteins (UCPs) belong to a discrete family within the mitochondrial anion carrier superfamily. Several uncoupling protein types have been found in mitochondria from mammals and plants, as well as in fishes, fungi, and protozoa. Mammalian UCPs and plant uncoupling proteins (PUMPs) form five distinct subfamilies. Only subfamily III contains both plant and animal uncoupling proteins, as well as UCPs from primitive eukaryotic organisms, which suggest that this group may represent an ancestral cluster from which other UCPs/PUMPs may have evolved. Genetic data indicate that UCPs/PUMPs are regulated at the transcriptional, post-transcriptional, and translational levels. Tissue/organ- and stress-specific gene expression suggests that UCPs/PUMPs are involved in the general balance of basic energy expenditure, protection against reactive oxygen species, and thermogenesis. Finally, the simultaneous occurrence of PUMP and alternative oxidase, another energy-dissipating system in plant mitochondria, raises the question of their response to biotic and abiotic stress at the transcriptional and functional levels.
Subject: expression profile
transcription regulation
uncoupling protein
Country: EUA
Editor: Springer/plenum Publishers
Citation: Bioscience Reports. Springer/plenum Publishers, v. 25, n. 41732, n. 209, n. 226, 2005.
Rights: aberto
Identifier DOI: 10.1007/s10540-005-2886-5
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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