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Type: Artigo de periódico
Title: Gastroprotective effects of essential oil from Protium heptaphyllum on experimental gastric ulcer models in rats
Author: Araujo, DAOV
Takayama, C
De-Faria, FM
Socca, EAR
Dunder, RJ
Manzo, LP
Luiz-Ferreira, A
Souza-Brito, ARM
Abstract: Peptic ulcers are a common disorder of the entire gastrointestinal tract, its etiology has not been completely elucidated. The basic physiopathological of peptic ulcers result from an imbalance between some endogenous aggressive factor and cytoprotective factors. The treatment of this disease is usually done with antacids or proton pump, but are currently being used plants derivated compounds. We evaluated the gastroprotective properties and its possible mechanisms of action of the essential oil from Protium heptaphyllum (Aubl.) Marchand, Burseraceae (BB). The formation of ulcers, were evaluated in three experimental models, through the induction of gastric lesions by ethanol, nonsteroidal anti-inflammatory drugs and acetic acid. The mechanisms of action were evaluated through the pylorus ligature experiment, western blot, GSH, GR, SOD, GPx, MDA and MPO activities. BB significantly inhibited the formation of ulcers induced by the three different models, increased the GSH and GR levels and maintained the same levels of SOD and GPx of the sham group, inhibited MPO and MDA, did not produce significant modification in gastric juice content and showed increased COX-2 and EGF. BB exerts its gastroprotective activity, possibly, by increasing COX-2 and EGF expression and due to its possible antioxidant property.
Subject: essential oil
gastric ulcer
Protium heptaphyllum
Country: Brasil
Editor: Soc Brasileira Farmacognosia
Citation: Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 21, n. 4, n. 721, n. 729, 2011.
Rights: aberto
Identifier DOI: 10.1590/S0102-695X2011005000117
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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