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Type: Artigo de periódico
Title: Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice
Author: Vieira, KP
Zollner, ARDESL
Malaguti, C
Vilella, CA
Zollner, RD
Abstract: NOD (non-obese diabetic) mice develop type 1 diabetes mellitus spontaneously and with a strong similarity to the human disease. Differentiation and function of pancreas 0 cells are regulated by a variety of hormones and growth factors, including the nerve growth factor (NGF). Gangliosides have multiple immunomodulatory activities with immunosuppressive properties, decreasing lymphoproliferative responses and modulating cytokine production. In the present study, serum, pancreas islets and spleen mononuclear cells from NOD mice treated with monosialic ganglioside GM1 (100 mg/kg/day) and the group control which received saline solution were isolated to investigate the proinflammatory cytokines (IL-1 beta, IFN-gamma, IL-12, TNF-alpha, NGF and its high-affinity receptor TrkA, peri-islet Schwann cells components (GFAP, S100-beta) expression and the relationship with diabetes onset and morphological aspects. Our results suggest that GM1 administration to female NOD mice beginning at the 4th week of life is able to reduce the index of inflammatory infiltrate and consequently the expression of diabetes, modulating the expression of proinflammatory cytokines (IL-12, IFN-gamma, TNF-alpha( and IL-1 beta). Furthermore, GM1 increases GFAP, S-100 beta and NGF in pancreas islets, factors involved in beta cell survival. (c) 2008 Elsevier Ltd. All rights reserved.
Subject: cytokines
peri-islet Schwann cells
NOD mice and autoimmune diabetes
Country: Inglaterra
Editor: Academic Press Ltd Elsevier Science Ltd
Citation: Cytokine. Academic Press Ltd Elsevier Science Ltd, v. 42, n. 1, n. 92, n. 104, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.cyto.2008.01.009
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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