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Type: Artigo de periódico
Title: Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis
Author: Viegas, C
Bolzani, VD
Furlan, M
Barreiro, EJ
Young, MCM
Tomazela, D
Eberlin, MN
Abstract: The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Natural Products. Amer Chemical Soc, v. 67, n. 5, n. 908, n. 910, 2004.
Rights: fechado
Identifier DOI: 10.1021/np0303963
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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