Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/67613
Type: Artigo de periódico
Title: On cytoadhesion of Plasmodium vivax: raison d'etre?
Author: Costa, FTM
Lopes, SCP
Ferrer, M
Leite, JA
Martin-Jaular, L
Bernabeu, M
Nogueira, PA
Mourao, MPG
Fernandez-Becerra, C
Lacerda, MVG
del Portillo, H
Abstract: It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
Subject: Plasmodium vivax
malaria
cytoadherence
severe disease
Country: Brasil
Editor: Fundaco Oswaldo Cruz
Rights: aberto
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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