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Type: Artigo de periódico
Title: First total synthesis of Aspinolide B, a new pentaketide produced by Aspergillus ochraceus
Author: Pilli, RA
Victor, MM
de Meijere, A
Abstract: The first asymmetric total synthesis of Aspinolide B (1), a new 10-membered lactone discovered by chemical screening methods in the cultures of Aspergillus ochraceus, has been accomplished. The key steps included a selective Felkin-type addition of TMS-acetylene to aldehyde 3a and a Nozaki-Hiyama-Kishi coupling reaction to build the required 10-membered ring. This synthesis confirmed the absolute stereochemistry of aspinolide B, established through Helmchen's method and corrected its previously reported specific optical rotation.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Organic Chemistry. Amer Chemical Soc, v. 65, n. 19, n. 5910, n. 5916, 2000.
Rights: fechado
Identifier DOI: 10.1021/jo000327i
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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