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Type: Artigo de periódico
Title: Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter Polymorphisms among distinct ethnic groups from Brazil
Author: Fertrin, KY
Goncalves, MS
Saad, STO
Costa, FF
Abstract: A polymorphism in the promoter region of the UDP-glucuronosyltransferase 1 (UGT1A) gene is associated with Gilbert syndrome (GS), a benign form of mild unconjugated hyperbilirubinemia. We genotyped 157 individuals from Brazil, comprising 71 Caucasians, 54 African-derived subjects, and 32 Parakana Indians. Frequencies of the alelle (TA)7 associated with GS found in this study were 0.324, 0.407, and 0.328, respectively. The genotype frequencies differed significantly between Caucasians and African-derived individuals. The high frequencies of (TA)7 polymorphism among the three groups confirm previous data that this polymorphism is very ancient and appears to be distributed throughout the world. (C) 2002 Wiley-Liss, Inc.
Subject: Gilbert syndrome
(TA) polymorphism
Parakana Indians
Country: EUA
Editor: Wiley-liss
Citation: American Journal Of Medical Genetics. Wiley-liss, v. 108, n. 2, n. 117, n. 119, 2002.
Rights: fechado
Identifier DOI: 10.1002/ajmg.10209
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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