Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/67155
Type: Artigo de periódico
Title: Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat-fed mice
Author: Dragano, NRV
Marques, AYC
Cintra, DEC
Solon, C
Morari, J
Leite-Legatti, AV
Velloso, LA
Marostica, MR
Abstract: The peel of the native Brazilian fruit jaboticaba is rich in anthocyanins, which are known for their anti-obesity effects in animal models. The aim of the present study was to evaluate the effects of freeze-dried jaboticaba peel powder (FDJPP) on a number of metabolic parameters in a model of diet-induced obesity. Mice (n 8 per group) were initially fed on a high-fat diet (HFD, 35% w/w) for 4 weeks and then switched to a HFD supplemented with FDJPP (1, 2 or 4% w/w) for an additional 6 weeks. Energy intake, weight loss, glucose tolerance, insulin resistance and lipid profile were determined, and the results were evaluated using ANOVA and Tukey's tests. The FDJPP exerted no protective effect on HFD-induced weight gain, hyperleptinaemia and glucose intolerance. However, the supplementation was effective to reduce insulin resistance, as evidenced in the insulin tolerance test, and subsequently confirmed by improved signal transduction through the insulin receptor/insulin receptor substrate-1/Akt/forkhead box protein pathway and by the attenuation of HFD-induced inflammation in the liver, verified by lower expressions of IL-1 beta and IL-6 and decreased phosphorylated I kappa B-alpha protein levels in all jaboticaba-treated mice. These results suggest that FDJPP may exert a protective role against obesity-associated insulin resistance.
Subject: Jaboticaba
Obesity
Insulin resistance
Country: Inglaterra
Editor: Cambridge Univ Press
Rights: embargo
Identifier DOI: 10.1017/S0007114512005090
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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