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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFormation of nano and microstructures by polysorbate-chitosan associationpt_BR
dc.contributor.authorPicone, CSFpt_BR
dc.contributor.authorCunha, RLpt_BR
unicamp.author.emailrosiane@fea.unicamp.brpt_BR
unicamp.authorFranco Picone, Carolina Siqueira Cunha, Rosiane Lopes Univ Campinas UNICAMP, Fac Food Engn, Dept Food Engn, BR-13083862 Campinas, SP, Brazilpt_BR
dc.subjectSelf-assemblypt_BR
dc.subjectChitosanpt_BR
dc.subjectPolysorbatespt_BR
dc.subjectNanostructurespt_BR
dc.subjectMicrostructurespt_BR
dc.subject.wosSodium Dodecyl-sulfatept_BR
dc.subject.wosNonionic Sorbitan Esterspt_BR
dc.subject.wosNon-ionic Surfactantspt_BR
dc.subject.wosDrug-deliverypt_BR
dc.subject.wosSelf-diffusionpt_BR
dc.subject.wosAqueous-solutionspt_BR
dc.subject.wosMixed-solutionspt_BR
dc.subject.wosPhase-behaviorpt_BR
dc.subject.wosSystemspt_BR
dc.subject.wosMixturespt_BR
dc.description.abstractDifferent environmental conditions and polysorbate types were explored for the formation of nano and microstructures in association with chitosan. Systems composed of polysorbates (0-90% (w/v)) and an aqueous phase (10-90% (w/v)) containing polysaccharide (0.01-1% (w/v)) or not, were studied. First the effect of the hydrophobic polysorbate tail length on the properties of the self-assembled structures was evaluated, in order to determine the best component for interaction with the chitosan. The effect of p1-1(3 or 6.7) on such structural formations was then determined. Finally, the effect of chitosan concentration on the surfactant-polymer association was evaluated. The structures were characterized using rheological and conductivity measurements and by optical polarized microscopy, and their size was evaluated by dynamic light scattering. Polysorbate-20 tended to form nanoparticles whilst gel-like structures were observed in polysorbate-80 systems, which made it difficult to associate with the chitosan. Thus, the mixed systems were composed of polysorbate-20-chitosan. Structures with similar rheological properties, electrical conductivity and size were obtained with polysorbate-20 at both pH 3 and 6.7, therefore the mixed samples were prepared at pH 3, where the chitosan solubility was higher. Increasing the chitosan concentration in the mixed systems resulted in smaller and less polydispersed particles, due to the decrease in molecular mobility of the systems. These results suggest that nanoparticles with potential use for bioactive delivery could be formed by polysorbate-chitosan association. (C) 2012 Elsevier B.V. All rights reserved.pt
dc.relation.ispartofColloids And Surfaces A-physicochemical And Engineering Aspectspt_BR
dc.relation.ispartofabbreviationColloid Surf. A-Physicochem. Eng. Asp.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationFEB 5pt_BR
dc.identifier.citationColloids And Surfaces A-physicochemical And Engineering Aspects. Elsevier Science Bv, v. 418, n. 29, n. 38, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume418pt_BR
dc.description.firstpage29pt_BR
dc.description.lastpage38pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0927-7757pt_BR
dc.identifier.wosidWOS:000314010000005pt_BR
dc.identifier.doi10.1016/j.colsurfa.2012.11.019pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberFAPESP [2009/54137-1]pt
dc.description.sponsordocumentnumberCNPq [301869/2006-5]pt
dc.date.available2014-07-30T17:36:54Z
dc.date.available2015-11-26T16:44:56Z-
dc.date.accessioned2014-07-30T17:36:54Z
dc.date.accessioned2015-11-26T16:44:56Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T17:36:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:44:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/67055
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/67055-
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