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|Type:||Artigo de periódico|
|Title:||Formation of nano and microstructures by polysorbate-chitosan association|
|Abstract:||Different environmental conditions and polysorbate types were explored for the formation of nano and microstructures in association with chitosan. Systems composed of polysorbates (0-90% (w/v)) and an aqueous phase (10-90% (w/v)) containing polysaccharide (0.01-1% (w/v)) or not, were studied. First the effect of the hydrophobic polysorbate tail length on the properties of the self-assembled structures was evaluated, in order to determine the best component for interaction with the chitosan. The effect of p1-1(3 or 6.7) on such structural formations was then determined. Finally, the effect of chitosan concentration on the surfactant-polymer association was evaluated. The structures were characterized using rheological and conductivity measurements and by optical polarized microscopy, and their size was evaluated by dynamic light scattering. Polysorbate-20 tended to form nanoparticles whilst gel-like structures were observed in polysorbate-80 systems, which made it difficult to associate with the chitosan. Thus, the mixed systems were composed of polysorbate-20-chitosan. Structures with similar rheological properties, electrical conductivity and size were obtained with polysorbate-20 at both pH 3 and 6.7, therefore the mixed samples were prepared at pH 3, where the chitosan solubility was higher. Increasing the chitosan concentration in the mixed systems resulted in smaller and less polydispersed particles, due to the decrease in molecular mobility of the systems. These results suggest that nanoparticles with potential use for bioactive delivery could be formed by polysorbate-chitosan association. (C) 2012 Elsevier B.V. All rights reserved.|
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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