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Type: Artigo de periódico
Title: Formation of cytotoxic intermediates in the course of photodecomposition of a nitroheterocyclic antiseptic quinifuryl
Author: Daghastanli, NA
Degterev, IA
Olivera, GB
Seabra, AB
de Oliveira, MG
Borissevitch, IE
Abstract: Phototoxicity of quinifuryl, 2-(5'-nitro-2'-furanyl)ethenyl-4-{n-[4'-(n,n-diethylamino)-1-methylbutyl]carbamoyl}quinoline, towards tumor cells has already been shown. Since no cytotoxicity of the final products of its photodecomposition was observed, we have supposed that cytotoxicity should be caused by reactive intermediates in the quinifuryl photolysis. We succeeded in detecting three species in the course of quinifuryl photolysis: singlet oxygen (1 A.), nitric oxide (NO) and superoxide anion (02 Singlet oxygen was detected by its specific phosphorescence in the course of the quinifuryl photoexcitation in both acetonitrile and aqueous solutions with lifetimes of 74.7 mu s and 3.5 mu s, respectively. The quantum yield of the (1)Delta g formation in water was 0.29 +/- 0.03. Nitric oxide release was detected by specific chemiluminescence of excited radical *NO2, formed in the reaction of NO with O-3. The yield of NO was 0.45 +/- 0.03 mol/mol of photodecomposed quinifuryl. The formation Of O-2(center dot-) was detected spectrophotometrically (epinephrine oxidation to adrenochrome) and by EPR (stable nitroxyl free radical formation). (c) 2006 Elsevier B.V. All rights reserved.
Subject: quinifuryl photodecomposition
cytotoxic intermediates
superoxide anion free radical
singlet oxygen
nitric oxide
Country: Suíça
Editor: Elsevier Science Sa
Citation: Journal Of Photochemistry And Photobiology A-chemistry. Elsevier Science Sa, v. 184, n. 41671, n. 98, n. 104, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.jphotochem.2006.04.004
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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