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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFilm coating of theophylline pellets in a pulsed fluid bed coaterpt_BR
dc.contributor.authorNitz, Mpt_BR
dc.contributor.authorTaranto, OPpt_BR
unicamp.author.emailnitz@maua.brpt_BR
unicamp.authorNitz, Marcello Maua Inst Technol, Maua Sch Engn, BR-09580900 Sao Paulo, Brazilpt_BR
unicamp.authorTaranto, Osvaldir Pereira Univ Estadual Campinas, Sch Chem Engn, Lab Thermo Fluid Dynam & Drying, BR-13083970 Sao Paulo, Brazilpt_BR
dc.subjectaqueous film coatingpt_BR
dc.subjectfactorial designpt_BR
dc.subjectsustained releasept_BR
dc.subjectpulsed fluid bedpt_BR
dc.subject.wosAqueous Polymer Dispersionspt_BR
dc.subject.wosReleasept_BR
dc.subject.wosOptimizationpt_BR
dc.subject.wosParameterspt_BR
dc.subject.wosDesignpt_BR
dc.description.abstractA four-section pulsed fluid bed (PFB) dryer was employed in the film coating of granules. Particles of 1.28 and 1.62 mean diameter, containing, respectively, 6.8 and 9.2% of theophylline, were coated with a commercial polyvinyl acetate aqueous dispersion (Kollicoat SR 30 D, by BASF). The release profiles were related to the pulsation frequency (500 and 800 rpm), suspension flow rate (6.0 and 8.0 mL/min) and particle mean diameter (1.28 and 1.62 mm). A complete 23 factorial design was employed. Airflow rate and temperature were held constant at 500 m(3)(STP)/min and 60 degrees C, as well as the atomizing conditions. Results showed that all the studied variables influenced the drug release rate. The highest amount of drug released after 8 h of dissolution (83%) was achieved with the 1.28 mm particles, with frequency at 800 rpm and suspension flow rate at 6.0 mL/min. The lowest (37%) was achieved with the 1.62 mm particles, at 800 rpm with a flow rate of 8.0 mL/min. Both coated and uncoated beads were observed with a scanning electron microscope. The images showed that the film smoothes the particles surface but does not significantly increase the diameter. (C) 2007 Elsevier B.V. All rights reserved.pt
dc.relation.ispartofChemical Engineering And Processingpt_BR
dc.relation.ispartofabbreviationChem. Eng. Process.pt_BR
dc.publisher.cityLausannept_BR
dc.publisher.countrySuíçapt_BR
dc.publisherElsevier Science Sapt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationAUGpt_BR
dc.identifier.citationChemical Engineering And Processing. Elsevier Science Sa, v. 47, n. 8, n. 1418, n. 1425, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume47pt_BR
dc.description.issuenumber8pt_BR
dc.description.firstpage1418pt_BR
dc.description.lastpage1425pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0255-2701pt_BR
dc.identifier.wosidWOS:000257050800027pt_BR
dc.identifier.doi10.1016/j.cep.2007.10.007pt_BR
dc.date.available2014-11-19T14:40:27Z
dc.date.available2015-11-26T17:06:45Z-
dc.date.accessioned2014-11-19T14:40:27Z
dc.date.accessioned2015-11-26T17:06:45Z-
dc.description.provenanceMade available in DSpace on 2014-11-19T14:40:27Z (GMT). No. of bitstreams: 1 WOS000257050800027.pdf: 1596423 bytes, checksum: 4ea637c1522f65ef06f8319f2bc53774 (MD5) Previous issue date: 2008en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:06:45Z (GMT). No. of bitstreams: 2 WOS000257050800027.pdf: 1596423 bytes, checksum: 4ea637c1522f65ef06f8319f2bc53774 (MD5) WOS000257050800027.pdf.txt: 28940 bytes, checksum: 7bc6836b871913c140f8a06693e95f4c (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66953pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/66953
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66953-
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