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Type: Artigo de periódico
Title: Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection
Author: Moreno, YF
Sgarbieri, VC
da Silva, MN
Toro, AADC
Vilela, MMS
Abstract: HIV infection is associated with subnormal GSH levels. An increase in glutathione levels has been observed in HIV-infected adults under oral whey protein supplementation. We studied the features associated with a whey protein concentrate supplementation in children with rapidly progressive AIDS. A prospective double-blind clinical trial was carried out for 4 months with 18 vertically HIV-infected children (1.98-6.37 years), under antiretroviral therapy, who had received whey protein, maltodextrin (placebo) or none. Erythrocyte glutathione concentration, T lymphocyte counts (CD4(+) and CD8(+)) and occurrence of associated co-infections were evaluated. Wilcoxon's and Fischer's Exact tests were used to assess differences between whey protein-supplemented and control (placebo and non-supplemented) groups. A significant median increase of 16.14 mg/dl (p = 0.018) in erythrocyte glutathione levels was observed in the whey protein-supplemented group; the TCD4/CD8 lymphocyte ratio showed a non significant increase and lower occurrence of associated co-infections was also observed. In conclusion, whey protein concentrate supplementation can stimulate glutathione synthesis and, possibly, decrease the occurrence of associated co-infections.
Country: Inglaterra
Editor: Oxford Univ Press
Citation: Journal Of Tropical Pediatrics. Oxford Univ Press, v. 52, n. 1, n. 34, n. 38, 2006.
Rights: fechado
Identifier DOI: 10.1093/tropej/fmi074
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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