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Type: Artigo de periódico
Title: Fatty acid-mediated uncoupling of potato tuber mitochondria
Author: Saviani, EE
Martins, IS
Abstract: The present work examined whether the ATP/ADP carrier, other than the plant uncoupling mitochondrial protein, participates in free fatty acid-mediated uncoupling of potato tuber mitochondria. The basal respiration rate of succinate-energized mitochondria was stimulated by a low concentration of palmitate (20 mu M). This uncoupling was reversed by 10 mu M carboxyatractyloside and by the subsequent addition of 0.1% bovine serum albumin. The decrease in membrane potential caused by palmitate was suppressed by carboxyatractyloside (1 mu M) and, to a lesser degree, by bongkrekate (20 mu M). GTP could also reversed this decrease via a carboxyatractyloside-independent mechanism. These results indicate that the ATP/ADP carrier, along with the plant uncoupling mitochondrial protein, participates in the protonophoric action of palmitate in potato tuber mitochondria.
Subject: FFA-mediated uncoupling
ATP/ADP mitochondrial carrier
plant uncoupling mitochondrial protein
potato tuber mitochondria
Country: Australia
Editor: Academic Press Aust
Citation: Biochemistry And Molecular Biology International. Academic Press Aust, v. 44, n. 4, n. 833, n. 839, 1998.
Rights: fechado
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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