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Type: Artigo de periódico
Title: Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings
Author: Silva, SD
Perez, DE
Nishimoto, IN
Alves, FA
Pinto, CAL
Kowalski, LP
Graner, E
Abstract: BACKGROUND: Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for some tumors. This study investigated whether FAS immunohistochemical expression is correlated with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The clinical features of 102 patients with OSCC of the tongue treated in a single institution were obtained from the medical records and all histopathological diagnoses were reviewed. The expression of FAS was determined by the standard immunoperoxidase technique in formalin-fixed and paraffin-embedded specimens and correlated with the clinicopathological characteristics of the tumors. RESULTS: Eighty-one cases (79.41%) were positive for FAS. Microscopic characteristics such as histological grade (P < 0.05), lymphatic permeation (P < 0.001), perineural infiltration (P < 0.05), and nodal metastasis (P < 0.02) were associated with FAS status. A significantly lower survival probability for patients with advanced clinical stage (log-rank test, P < 0.001), lymph nodes metastasis (log-rank test, P < 0.001), presence of vascular permeation (log-rank test, P = 0.05), and perineural invasion (log-rank test, P = 0.01) was observed in the studied samples. CONCLUSION: The expression of FAS in OSCC of the tongue is associated with the microscopic characteristics that determine disease progression and prognosis.
Subject: oral squamous cell carcinoma
fatty acid synthase
oral cancer
Country: Inglaterra
Editor: Blackwell Publishing
Citation: Oral Diseases. Blackwell Publishing, v. 14, n. 4, n. 376, n. 382, 2008.
Rights: fechado
Identifier DOI: 10.1111/j.1601-0825.2007.01395.x
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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