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|Type:||Artigo de periódico|
|Title:||HLA-G Expression in the Skin of Patients with Systemic Sclerosis|
|Author:||WASTOWSKI, Isabela J.|
SAMPAIO-BARROS, Percival D.
AMSTALDEN, Eliane M. I.
PALOMINO, Gustavo Martelli
MARQUES-NETO, Joao Francisco
CRISPIM, Janaina C. O.
BIRAL, Ana C.
RASSI, Diane M.
CAROSELLA, Edgardo D.
DONADI, Eduardo A.
|Abstract:||Objective. To determine HLA-G expression in skin biopsies from patients with systemic sclerosis (SSc), and its association with epidemiological, clinical, and laboratory variables and survival. Methods. Paraffin-embedded skin biopsies obtained from 21 SSc patients (14 limited SSc, 7 diffuse SSc) and from 28 healthy controls were studied. HLA-G expression was evaluated by immunohistochemistry. Results. HLA-G molecules were detected in 57% of skin biopsies from patients with SSc (9 from limited SSc, 3 from diffuse SSc), whereas no control sample expressed HLA-G (p = 0.000004). In patients, HLA-G molecules were consistently observed within epidermal and some dermal cells. HLA-G expression was associated with a lower frequency of vascular cutaneous ulcers (p = 0.0004), telangiectasias (p = 0.008), and inflammatory polyarthralgia (p = 0.02). After a 15-year followup, SSc patients who exhibited HLA-G survived longer than patients who did not. Conclusion. HLA-G is expressed in skin biopsies from patients with SSc, and this is associated with a better disease prognosis. This Suggests a Modulatory role of HLA-G in SSc, as observed in other skin disorders. (First Release April 15 2009; J Rheumatol 2009;36:1230-4; doi:10.3899/jrheum.080552)|
|Editor:||J RHEUMATOL PUBL CO|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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