Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/668
Type: Artigo de periódico
Title: HLA-G Expression in the Skin of Patients with Systemic Sclerosis
Author: WASTOWSKI, Isabela J.
SAMPAIO-BARROS, Percival D.
AMSTALDEN, Eliane M. I.
PALOMINO, Gustavo Martelli
MARQUES-NETO, Joao Francisco
CRISPIM, Janaina C. O.
BIRAL, Ana C.
RASSI, Diane M.
CAROSELLA, Edgardo D.
MOREAU, Philippe
DONADI, Eduardo A.
Abstract: Objective. To determine HLA-G expression in skin biopsies from patients with systemic sclerosis (SSc), and its association with epidemiological, clinical, and laboratory variables and survival. Methods. Paraffin-embedded skin biopsies obtained from 21 SSc patients (14 limited SSc, 7 diffuse SSc) and from 28 healthy controls were studied. HLA-G expression was evaluated by immunohistochemistry. Results. HLA-G molecules were detected in 57% of skin biopsies from patients with SSc (9 from limited SSc, 3 from diffuse SSc), whereas no control sample expressed HLA-G (p = 0.000004). In patients, HLA-G molecules were consistently observed within epidermal and some dermal cells. HLA-G expression was associated with a lower frequency of vascular cutaneous ulcers (p = 0.0004), telangiectasias (p = 0.008), and inflammatory polyarthralgia (p = 0.02). After a 15-year followup, SSc patients who exhibited HLA-G survived longer than patients who did not. Conclusion. HLA-G is expressed in skin biopsies from patients with SSc, and this is associated with a better disease prognosis. This Suggests a Modulatory role of HLA-G in SSc, as observed in other skin disorders. (First Release April 15 2009; J Rheumatol 2009;36:1230-4; doi:10.3899/jrheum.080552)
Subject: SYSTEMIC SCLEROSIS
HLA-G
AUTOIMMUNITY
Country: Canadá
Editor: J RHEUMATOL PUBL CO
Citation: JOURNAL OF RHEUMATOLOGY, v.36, n.6, p.1230-1234, 2009
Rights: fechado
Identifier DOI: 10.3899/jrheum.080552
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000266891500024&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.3899/jrheum.080552
Date Issue: 2009
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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