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Type: Artigo de periódico
Title: Family-based association study for bipolar affective disorder
Author: Secolin, R
Banzato, CEM
Oliveira, MCM
Bittar, MFR
Santos, ML
Dalgalarrondo, P
Lopes-Cendes, I
Abstract: In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio = 2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences. Psychiatr Genet 20:126-129 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Subject: genetics
mood disorders
pedigree disequilibrium test
single nucleotide polymorphisms
Country: EUA
Editor: Lippincott Williams & Wilkins
Citation: Psychiatric Genetics. Lippincott Williams & Wilkins, v. 20, n. 3, n. 126, n. 129, 2010.
Rights: fechado
Identifier DOI: 10.1097/YPG.0b013e32833a2050
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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