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Type: Artigo de periódico
Title: Factor V Leiden is not common in children with portal vein thrombosis
Author: Seixas, CA
Hessel, G
Ribeiro, CC
Arruda, VR
AnnichinoBizzacchi, JM
Abstract: Portal vein thrombosis (PVT) is a rare condition affecting both children and adults, and occurs in association with a wide variety of clinical situations. On the other hand, the development of PVT in patients under these situations indicates that other contributing factors could be envolved. Recently a missense mutation in the factor V gene (1691G-->A), known as factor V Leiden, has been identified and results in abnormal factor V product, resistant to proteolytic inactivation by activated protein C and thus predisposes to thrombosis. This study was carried out to verify if children with PVT have an increase in frequency of factor V Leiden. Allele-specific restriction analysis and single strand conformational polymorphism (SSCP) were used to test for factor V Leiden in 20 children with PVT and 64 normal children. None of the PVT children were heterozygous or homozygous for the factor V Leiden, and one control child was heterozygous. This study demonstrates that factor V Leiden is not common in children with PVT, and is not a prerequisite for this thrombotic event.
Country: Alemanha
Editor: F K Schattauer Verlag Gmbh
Citation: Thrombosis And Haemostasis. F K Schattauer Verlag Gmbh, v. 77, n. 2, n. 258, n. 261, 1997.
Rights: fechado
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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