Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/66630
Type: Artigo de periódico
Title: F-19 DOSY NMR analysis for spin systems with (n)J(FF) couplings
Author: Dal Poggetto, G
Favaro, DC
Nilsson, M
Morris, GA
Tormena, CF
Abstract: NMR is a powerful method for identification and quantification of drug components and contaminations. These problems present themselves as mixtures, and here, one of the most powerful tools is DOSY. DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY analysis as F-19 spectra are typically very sparse. Here, we demonstrate the use of a modified F-19 DOSY experiment (on the basis of the Oneshot sequences) for various fluorinated benzenes. For compounds with significant (n)J(FF) coupling constants, as is common, the undesirable J-modulation can be efficiently suppressed using the Oneshot45 pulse sequence. This investigation highlights F-19 DOSY as a valuable and robust method for analysis of molecular systems containing fluorine atoms even where there are large fluorine-fluorine couplings. Copyright (c) 2014 John Wiley & Sons, Ltd.
Subject: DOSY
19F
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1002/mrc.4047
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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