Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/66625
Type: Artigo de periódico
Title: F A S N expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions
Author: Falci, SGM
Mesquita, ATM
de Andrade, BAB
de Miranda, JL
Leon, JE
de Almeida, OP
dos Santos, CRR
Abstract: Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.
Subject: Giant cell lesion
Immunohistochemistry
Angiogenesis
Lymphangiogenesis
Fatty acid synthase
Country: Brasil
Editor: Univ Sao Paulo Fac Odontologia Bauru
Rights: fechado
Identifier DOI: 10.1590/1678-7757201130509
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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