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Type: Artigo de periódico
Title: Extraction of indole alkaloids from Tabernaemontana catharinensis using supercritical CO2 plus ethanol: an evaluation of the process variables and the raw material origin
Author: Pereira, CG
Marques, MOM
Barreto, AS
Siani, AC
Fernandes, EC
Meireles, MAA
Abstract: Indole alkaloids from Tabernaemontana catharinensis, collected from different places, were extracted using a mixture of supercritical CO2 plus ethanol. The effects of the process variables: temperature, pressure, solvent flow rate, and percentage of cosolvent on the total yield, chemical composition of the extract, and extraction kinetics were determined. The extracts were solvent-partitioned and their composition analyzed by TLC, GC-MS and H-1 and C-13 NMR. Voacangine and coronaridine were identified as the major compounds in the extracts; the individual alkaloids were quantified by GC-FID using external standard. At 250 bar and 45 degreesC the largest yield (1.29%) and the faster extraction rate were obtained; increasing the percentage of cosolvent improved the extraction rate as well as the yield. Employing an intermittent process consisting in six pressurization-depressurization steps appreciably reduced the total extraction time. (C) 2003 Elsevier B.V. All rights reserved.
Subject: supercritical extraction
indole alkaloids
tabernaemontana catharinensis
Country: Holanda
Editor: Elsevier Science Bv
Citation: Journal Of Supercritical Fluids. Elsevier Science Bv, v. 30, n. 1, n. 51, n. 61, 2004.
Rights: fechado
Identifier DOI: 10.1016/S0896-8446(03)00112-8
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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