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Type: Artigo de periódico
Title: Expressions of the VLA-4, LFA-1 and Mac-1 integrins in eosinophil migration in a case of chronic eosinophilic leukaemia
Author: Lima, CSP
Franco-Penteado, CF
Canalli, AA
Conran, N
Lorand-Metze, I
Costa, FF
Ferreira, HHA
Abstract: Migration of eosinophil (Eo) into tissues is a hallmark of chronic eosinophilic leukaemia (CEL), but the exact mechanism involved in cell migration is unknown. We report on a patient with CEL who presented high expressions of VLA-4, LFA-1 and Mac-1 integrins on the Eo surface, increased chemotaxis of Eo to eotaxin, decreased chemotaxis of Eo after inhibition of the cyclic guanosine monophosphate (cGMP), and a high level of intracellular cGMP. These findings suggest that an upregulation of expression of these integrins on Eo surface and a high intracellular level of cGMP may be involved in the increased Eo migration observed in our CEL patient. However, the definitive roles of these molecules in the proliferation and migration of Eo in CEL disease require wider confirmation by analysis of additional patients with the disease. (c) 2006 Elsevier Ltd. All rights reserved.
Subject: chronic eosinophilic leukaemia
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Leukemia Research. Pergamon-elsevier Science Ltd, v. 31, n. 5, n. 695, n. 697, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2006.07.025
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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