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Type: Artigo de periódico
Title: Expression of New Red Cell-Related Genes in Erythroid Differentiation
Author: De Andrade, T
Moreira, L
Duarte, A
Lanaro, C
De Albuquerque, D
Saad, S
Costa, F
Abstract: Using a suppression subtractive hybridization method, we have previously identified genes differentially expressed in erythroid cells heterozygous for large deletions in beta-like globin cluster. Herein, we investigated the expression of four newly detected red cell-related genes in erythroid differentiation. ARID1B and TSPYL1, genes with chromatin remodeling properties, presented similar patterns of expression with an upregulation after erythropoietin (EPO) addition, similar to previous data found in reticulocytes. ZHX2, a transcriptional repressor, was downregulated, and a redoxin-related gene, SH3BGRL2, had higher levels of expression on differentiation. These are the first investigations of these newly described genes in erythroid differentiation and demonstrate that the expression of these genes is affected by EPO stimulation. These genes may participate in globin regulation and may be important in the normal physiology of erythrocytes.
Subject: Globin
Erythroid differentiation
Chromatin remodeling
Oxidative stress
Country: EUA
Editor: Springer/plenum Publishers
Citation: Biochemical Genetics. Springer/plenum Publishers, v. 48, n. 41671, n. 164, n. 171, 2010.
Rights: fechado
Identifier DOI: 10.1007/s10528-009-9310-y
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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