Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/66480
Type: Artigo de periódico
Title: Expression of matrix metalloproteases-2 and-9 in horse hoof laminae after intestinal obstruction, with or without Hydrocortisone treatment
Author: Laskoski, LM
Valadao, CAA
Vasconcelos, RD
Ferrucci, D
Silva, JAF
Machado, DRS
Doria, RGS
Mendonca, FD
Abstract: Twenty horses were used in the experiment, for composed control group, (Cg) instrumented group, (Ig; without intestinal obstruction), treated group (Tg; submitted to intestinal obstruction and hydrocortisone treatment) and non-treated group (Ntg; submitted to intestinal obstruction without treatment). Immunohistochemistry and zymography techniques were used for researches on MMPs 2 and 9 in horse hoof laminae. There was an increase in the expression of MMP-2 in animals of Tg and Ntg. MMP-9 increased on animals from groups Ntg and Ig, however there was no rise of this MMP on the Tg when compared to the other groups in the immunohistochemistry analysis. Based on the results, it was observed that the intestinal injury caused by enterotomy and intestinal obstruction raise the quantities of MMPs in the hoof laminae.
Subject: laminitis
metalloprotease
horse
zymography
immunohistochemistry
Country: Brasil
Editor: Univ Federal Santa Maria
Rights: aberto
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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