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Type: Artigo de periódico
Title: Expression of hypoxia-inducible factor-1 alpha in the cutaneous lesions of BALB/c mice infected with Leishmania amazonensis
Author: Arrais-Silva, WW
Paffaro, VA
Yamada, AT
Giorgio, S
Abstract: The hypoxia-inducible factor-1alpha (HIF-1alpha) is expressed in response to hypoxia and has been recently demonstrated in a variety of cells such as tumor cells and tumor-associated macrophages. Several characteristics of leishmanial lesions in humans and in animal models, such as microcirculation impairment, metabolic demand for leukocyte infiltration into infected tissue, parasite proliferation, and secondary bacterial infection, are strong indications of a hypoxic microenvironment in the lesions. We evaluated HIF-1alpha expression in the cutaneous lesions of BALB/c mice during Leishmania amazonensis infection. Immunohistochemical analyses of the lesions demonstrated, only in the later stages of infection when the lesion size is maximal and parasite burden is enormous and massive numbers of recruited macrophages and ulcers are observed, positive HIF-1alpha-infected cells throughout the lesions. HIF-1alpha is expressed mainly in the cytoplasm and around parasites inside the parasitophorous vacuoles of macrophages. This is the first evidence that macrophages in the microenvironment of lesions caused by a parasite produce a hypoxia-inducible factor. (C) 2004 Elsevier Inc. All rights reserved.
Subject: Leishmania amazonensis
murine leishmaniasis
chronic cutaneous lesions
parasitic diseases
parasitophorous vacuoles
immunohistochemistry studies
hypoxia-inducible factor-1 alpha
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Experimental And Molecular Pathology. Academic Press Inc Elsevier Science, v. 78, n. 1, n. 49, n. 54, 2005.
Rights: fechado
Identifier DOI: 10.1016/j.yexmp.2004.09.002
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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