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Type: Artigo de periódico
Title: Expression of fatty acid synthase (FASN) in oral nevi and melanoma
Author: de Andrade, BAB
Leon, JE
Carlos, R
Delgado-Azanero, W
Mosqueda-Taylor, A
Graner, E
de Almeida, OP
Abstract: OBJECTIVE: The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. MATERIALS AND METHODS: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. RESULTS: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. CONCLUSION: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi. Oral Diseases (2011) 17, 808-812
Subject: melanocytic nevi
fatty acid synthase
Country: EUA
Editor: Wiley-blackwell
Citation: Oral Diseases. Wiley-blackwell, v. 17, n. 8, n. 808, n. 812, 2011.
Rights: fechado
Identifier DOI: 10.1111/j.1601-0825.2011.01841.x
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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