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Type: Artigo de periódico
Title: Excess androgen during perinatal life alters steroid receptor expression, apoptosis, and cell proliferation in the uteri of the offspring
Author: Guerra, MT
Sanabria, M
Grossman, G
Petrusz, P
Kempinas, WD
Abstract: Exposure to environmental chemicals may contribute to reproductive disorders, especially when it occurs in critical periods of development. The female reproductive system can be a target for androgens derived from environmental contaminants or pathological conditions. The purpose of this study was to assess the long-term effects of androgens on uterine tissue after maternal exposure limited to the time of gestation and lactation. Pregnant Wistar rats were treated with testosterone propionate (TP) at 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg or corn oil (vehicle), s.c., from gestational day 12 until the end of lactation. The results show changes in the pattern of expression of receptors for estrogen, progesterone, and androgen at all doses tested, and decreases in both apoptosis and cell proliferation indices at 0.1 and 0.2 mg/kg. We conclude that early TP exposure, under these experimental conditions, causes changes in cellular and molecular parameters that are essential for normal uterine function in the adult. (C) 2013 Elsevier Inc. All rights reserved.
Subject: Female reproduction
Hyper-androgenic condition
Steroid receptors
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Reproductive Toxicology. Pergamon-elsevier Science Ltd, v. 40, n. 1, n. 7, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.reprotox.2013.05.001
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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