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|Type:||Artigo de periódico|
|Title:||Evolutionary hypothesis for Chiari type I malformation|
|Abstract:||Chiari I malformation (CM-I) is classically defined as a cerebellar tonsillar herniation (>= 5 mm) through the foramen magnum. A decreased posterior fossa volume, mainly due to basioccipital hypoplasia and sometimes platybasia, leads to posterior fossa overcrowding and consequently cerebellar herniation. Regardless of radiological findings, embryological genetic hypothesis or any other postulations, the real cause behind this malformation is yet not well-elucidated and remains largely unknown. The aim of this paper is to approach CM-I under a broader and new perspective, conjoining anthropology, genetics and neurosurgery, with special focus on the substantial changes that have occurred in the posterior cranial base through human evolution. Important evolutionary allometric changes occurred during brain expansion and genetics studies of human evolution demonstrated an unexpected high rate of gene flow interchange and possibly interbreeding during this process. Based upon this review we hypothesize that CM-I may be the result of an evolutionary anthropological imprint, caused by evolving species populations that eventually met each other and mingled in the last 1.7 million years. (C) 2013 Elsevier Ltd. All rights reserved.|
|Citation:||Medical Hypotheses. Churchill Livingstone, v. 81, n. 4, n. 715, n. 719, 2013.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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