Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/66181
Type: Artigo de periódico
Title: Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures
Author: Lours-Calet, C
Alvares, LE
El-Hanfy, AS
Gandesha, S
Walters, EH
Sobreira, DR
Wotton, KR
Jorge, EC
Lawson, JA
Lewis, AK
Tada, M
Sharpe, C
Kardon, G
Dietrich, S
Abstract: The vertebrate head trunk interface (occipital region) has been heavily remodelled during evolution, and its development is still poorly understood. In extant jawed vertebrates, this region provides muscle precursors for the throat and tongue (hypopharyngeal/hypobranchial/hypoglossal muscle precursors, HMP) that take a stereotype path rostrally along the pharynx and are thought to reach their target sites via active migration. Yet, this projection pattern emerged in jawless vertebrates before the evolution of migratory muscle precursors. This suggests that a so far elusive, more basic transport mechanism must have existed and may still be traceable today. Here we show for the first time that all occipital tissues participate in well-conserved cell movements. These cell movements are spearheaded by the occipital lateral mesoderm and ectoderm that split into two streams. The rostrally directed stream projects along the floor of the pharynx and reaches as far rostrally as the floor of the mandibular arch and outflow tract of the heart. Notably, this stream leads and engulfs the later emerging HMP, neural crest cells and hypoglossal nerve. When we (i) attempted to redirect hypobranchial/hypoglossal muscle precursors towards various attractants, (ii) placed non-migratory muscle precursors into the occipital environment or (iii) molecularly or (iv) genetically rendered muscle precursors non-migratory, they still followed the trajectory set by the occipital lateral mesoderm and ectoderm. Thus, we have discovered evolutionarily conserved morphogenetic movements, driven by the occipital lateral mesoderm and ectoderm, that ensure cell transport and organ assembly at the head trunk interface. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Subject: Evolution of vertebrate developmental mechanisms
Head-trunk interface
Morphogenetic movements
Occipital lateral mesoderm
Occipital somites
Occipital ectoderm
Occipital neural crest
Hypobranchial/hypoglossal muscle
Migratory muscle precursors
Floor of pharynx
Pharyngeal arches
Circumpharyngeal route
Zebrafish
Xenopus
Chicken
Mouse
Country: EUA
Editor: Academic Press Inc Elsevier Science
Rights: fechado
Identifier DOI: 10.1016/j.ydbio.2014.03.003
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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