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Type: Artigo de periódico
Title: Evidence of memory impairment in asymptomatic individuals with hippocampal atrophy
Author: Alessio, A
Kobayashi, E
Damasceno, BP
Lopes-Cendes, I
Cendes, F
Abstract: Our objective was to investigate if MRI-determined hippocampal atrophy (HA) is associated with memory deficits independent of seizure frequency. We studied three groups of individuals: (1) 10 asymptomatic first-degree relatives of patients with familial mesial temporal lobe epilepsy (FMTLE), all of them with HA; (2) 14 patients with benign FMTLE, 9 with HA, and 5 with normal hippocampal volumes; and (3) 16 patients with refractory FMTLE, all but one with HA. HA was associated with lower scores on general memory (P = 0.015), verbal memory (P = 0.020), and delayed recall (P = 0.028), even in those with no or few seizures in life. General linear model analyses showed that the interaction between seizure outcome and HA was associated with worse verbal memory (P = 0.029), visual memory (P = 0.022), and delayed recall (P = 0.039) as compared with each of these factors independently. Our findings suggest that seizures and HA are independently associated with memory impairment. (C) 2004 Elsevier Inc. All rights reserved.
Subject: temporal lobe epilepsy
hippocampal sclerosis
hippocampal atrophy
familial TLE
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Epilepsy & Behavior. Academic Press Inc Elsevier Science, v. 5, n. 6, n. 981, n. 987, 2004.
Rights: fechado
Identifier DOI: 10.1016/j.yebeh.2004.08.018
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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