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Type: Artigo de periódico
Title: New destruxins from the marine-derived fungus Beauveria felina
Author: Lira, SP
Vita-Marques, AM
Seleghim, MHR
Bugni, TS
LaBarbera, DV
Sette, LD
Sponchiado, SRP
Ireland, CM
Berlinck, RGS
Abstract: Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [P-MePro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(R),4(S)-5-chloro-2,4-dihydroxypentanoic acid residue in I could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis.
Subject: fungi
Beauveria felina
marine microorganisms
Country: Japão
Editor: Japan Antibiotics Research Assoc
Citation: Journal Of Antibiotics. Japan Antibiotics Research Assoc, v. 59, n. 9, n. 553, n. 563, 2006.
Rights: fechado
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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