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Type: Artigo de periódico
Title: Evidence for cross-reactivity between antigen derived from Trypanosoma cruzi and myelin basic protein in experimental Chagas disease
Author: Al-Sabbagh, A
Garcia, CAAC
Diaz-Bardales, BM
Zaccarias, C
Sakurada, JK
Santos, LMB
Abstract: Evidence for crossreactivity between antigen derived from Trypanosoma cruzi and myelin basic protein in experimental Chagas disease. Experimental Parasitology 89, 304-311. Some autoimmune diseases are thought to arise after an infection. Infectious agents can initiate a chronic inflammatory response associated with autoimmune reactions. Chagas disease, caused by the intracellular parasite Trypanosoma cruzi, is an excellent model for autoimmune disease induced by an infection. The chronic disease is characterized by rich inflammatory infiltrate in myocardial and nervous tissues, with virtually no demonstrable parasites. We were able to demonstrate the presence of antibody to myelin basic protein (MBP) in the serum from T. cruzi chronically infected mice. Lymphocytes from mice immunized with T. cruzi-derived soluble extract antigen (TCSE) proliferate in response to MBP in vitro. Lymphocytes from animals immunized with MBP also were activated by TCSE in vitro. By studying the overlapping peptides from the MBP molecule, we were able to identify two regions responsible for the cross-reactivity. (C) 1998 Academic Press.
Subject: myelin basic protein
Trypanosoma cruzi
antigenic mimicry
Country: EUA
Editor: Academic Press Inc
Citation: Experimental Parasitology. Academic Press Inc, v. 89, n. 3, n. 304, n. 311, 1998.
Rights: fechado
Identifier DOI: 10.1006/expr.1998.4279
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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