Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/66029
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.typeArtigopt_BR
dc.titleEvaluation of two different oxygen inspiratory fractions on the hemodynamic effects of N-omega-nitro-L-arginine methyl ester in anesthetized dogspt_BR
dc.contributor.authorZappellini, A.pt_BR
dc.contributor.authorDe Nucci, G.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorMoreno, H.pt_BR
dc.subjectHemodinâmicapt_BR
dc.subjectÓxido nítricopt_BR
dc.subjectPressão sanguíneapt_BR
dc.subject.otherlanguageHemodynamicspt_BR
dc.subject.otherlanguageNitric oxidept_BR
dc.subject.otherlanguageBlood pressurept_BR
dc.subject.wosLong Evans Ratspt_BR
dc.subject.wosRelaxing Factorpt_BR
dc.subject.wosPulmonary Circulationpt_BR
dc.subject.wosBlood-pressurept_BR
dc.subject.wosOxidept_BR
dc.subject.wosInhibitorspt_BR
dc.subject.wosReleasept_BR
dc.subject.wosArterypt_BR
dc.subject.wosInvivopt_BR
dc.subject.wosVeinpt_BR
dc.description.abstractThe effect of two different oxygen inspiratory fractions (FiO(2)=21% and 100%) on the hemodynamic responses induced by N(o)mega-nitro-L-arginine methyl ester (L-NAME) was investigated in anesthetized dogs. L-NAME (0.01-10.0mg/kg), but not D-NAME: induced dose-dependent changes in the hemodynamic parameters of the animals. At the highest dose, L-NAME increased mean arterial blood pressure in both room air (from 86.2-/+3.2 to 125.1-/+7.8 mmHg) and pure oxygen (from 100.0-/+7.5 to 139.0-/+3.2 mmHg) ventilated animals. L-NAME also increased systemic and pulmonary vascular resistances. These effects were accompanied by a decrease in cardiac output and bradycardia (37% and 31% decreases far pure oxygen and room air, respectively). However, there were no significant differences in the responses to L-NAME between the dogs ventilated with FiO(2)=21% and those ventilated with FiO(2)= 100%. L-NAME did not modify blood gas analyses, despite the expected difference in pO(2) levels between the two experimental groups of animals (3 times higher in the animals ventilated with pure oxygen). These results indicate that nitric oxide release accounts for the maintenance of hemodynamic function in the anesthetized dog, and that L-NAME-induced effects are not affected by hyperoxemiapt
dc.description.eventAssociação Brasileira de Divulgação Científicapt_BR
dc.relation.ispartofBrazilian Journal Of Medical And Biological Researchpt_BR
dc.relation.ispartofabbreviationBrazilian J. Med. Biol. Res.pt_BR
dc.publisher.citySao Paulopt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherAssoc Bras Divulg Cientificapt_BR
dc.date.issued1996pt_BR
dc.date.monthofcirculationJan.pt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 29, n. 1, n. 33, n. 39, 1996.pt_BR
dc.language.isoengpt_BR
dc.description.volume29pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage33pt_BR
dc.description.lastpage39pt_BR
dc.rightsfechadopt_BR
dc.sourcePUBMEDpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.eissn1414-431Xpt_BR
dc.identifier.wosidWOS:A1996TP48300005pt_BR
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pubmed/8731329pt_BR
dc.date.available2014-07-30T17:29:43Z
dc.date.available2015-11-26T16:47:10Z-
dc.date.accessioned2014-07-30T17:29:43Z
dc.date.accessioned2015-11-26T16:47:10Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T17:29:43Z (GMT). No. of bitstreams: 0 Previous issue date: 1996en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:47:10Z (GMT). No. of bitstreams: 0 Previous issue date: 1996en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66029
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66029-
dc.description.conferencedateBrasilpt_BR
dc.description.conferencelocationBrazilian journal of medical and biological researchpt_BR
dc.description.conferencelocalBrazilian J. med. biol. res.pt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source8731329-
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.type.formArtigo original-
dc.description.eventsponsorSão Paulo, SPpt_BR
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