Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65834
Type: Artigo de periódico
Title: Evaluation of in vitro toxicity of N,N-dimethyl-2-propen-1-amines isomers
Author: Oliveira, DA
Fernandes, AMAP
De Conti, R
Rodriguez, JA
Haun, M
Souza-Brito, ARM
De Castro, SL
Duran, N
Abstract: The trypanocidal activities of cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(phenyl)-N,N-dimethyl-2-propen-1-amine (Vb) and cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-bromophenyl)-N,N-dimethyl-2-propen-1-anine (Vg) appeared 6.3 and 3.5 fold more active than the trans-isomers, respectively Multi-endpoints for toxicity were also applied. Neutral red uptake (NRU), tetrazolium salt reduction (MTT), DNA content on V79 fibroblast cell culture and acute toxicity von E. coli were measured. The IC50 through DNA contents was lower for the cis-isomers in both series of compounds 5b: 7.8 mu M and 5g: 5.2 mu M). NRU values for derivative 5b in isomeric mixture shows the same value as the isolated isomers however, in the case of 5g a more significant toxicity of the cis-isomer was found. MTT values show that 5g is more toxic than 5b. In both cases, the acute toxicity of the trans-isomers was higher than that of the cis-isomers.
Country: Alemanha
Editor: Govi-verlag Gmbh
Rights: fechado
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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