Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65792
Type: Artigo de periódico
Title: Evaluation of cysticercus-specific IgG (total and subclasses) and IgE antibody responses in cerebrospinal fluid samples from patients with neurocysticercosis showing intrathecal production of specific IgG antibodies
Author: Suzuki, LA
Rossi, CL
Abstract: In the present study, an enzyme-linked immunosorbent assay (ELISA) standardized with vesicular fluid of Taenia solium cysticerci was used to screen for IgG (total and subclasses) and IgE antibodies in cerebrospinal fluid (CSF) samples from patients with neurocysticercosis showing intrathecal production of specific IgG antibodies and patients with other neurological disorders. The following results were obtained: IgG-ELISA: 100% sensitivity (median of the ELISA absorbances (MEA)=1.17) and 100% specificity; IgG(1)-ELISA: 72.7% sensitivity (MEA=0.49) and 100% specificity; IgG(2)-ELISA: 81.8% sensitivity (MEA=0.46) and 100% specificity; IgG(3)-ELISA: 63.6% sensitivity (MEA=0.12) and 100% specificity; IgG(4)-ELISA: 90.9% sensitivity (MEA=0.85) and 100% specificity; IgE-ELISA 93.8% sensitivity (MEA=0.60) and 100% specificity. There were no significant differences between the sensitivities and specificities in the detection of IgG-ELISA and IgE-ELISA, although in CSF samples from patients with neurocysticercosis the MEA of the IgG-ELISA was significantly higher than that of the IgE-ELISA. The sensitivity and MEA values of the IgG(4)-ELISA were higher than the corresponding values for the other IgG subclasses. Future studies should address the contribution of IgG(4) and IgE antibodies to the physiopathology of neurocysticercosis.
Subject: IgG
IgE
enzyme-linked immunosorbent assay
neurocysticercosis
Country: Brasil
Editor: Assoc Arquivos Neuro- Psiquiatria
Rights: aberto
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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