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Type: Artigo de periódico
Title: Evaluation of Antifungal Activity of Medicinal Plant Extracts Against Oral Candida albicans and Proteinases
Author: Hofling, JF
Mardegan, RC
Anibal, PC
Furletti, VF
Foglio, MA
Abstract: Proteinases produced by Candida albicans are one kind of virulence factor expressed that contribute to adherence and invasion of host tissue. Proteinase inhibitor of human immunodeficiency virus in experimental candidiasis suggested reduction in fungal infection, and medicinal plants could be a source of alternative agent to prevent diseases. In this study, we investigated the production of proteinases by C. albicans from clinical isolates and the action of plant extracts against strains of C. albicans and its synthesized proteinases, comparing with antifungal fluconazole and amphotericin B and proteinase inhibitors pepstatin A, amprenavir, and ritonavir. The results reported here showed that these extracts have a certain kind of action and that the search for new antifungal agents could be found at the plants.
Subject: Antifungal
Medicinal plants
Protease inhibitors
Country: Holanda
Editor: Springer
Citation: Mycopathologia. Springer, v. 172, n. 2, n. 117, n. 124, 2011.
Rights: fechado
Identifier DOI: 10.1007/s11046-011-9404-z
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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