Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65676
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFaro, Renato do Rego de Araujopt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.contributor.authorunicampFerraz, Jose Geraldo Paraisopt_BR
dc.contributor.authorunicampFaro, Flávio do Rego de Araujopt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.typeArtigopt_BR
dc.titleEthanol reduces the endothelin-B receptor-mediated increase in portal inflow resistance in the isolated, perfused canine liverpt_BR
dc.title.alternativeen
dc.contributor.authorFaro, R.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorFerraz, J.G.P.pt_BR
dc.contributor.authorFaro, F.pt_BR
dc.contributor.authorStella, H.J.pt_BR
dc.contributor.authorOpgennorth, T.J.pt_BR
dc.contributor.authorDe Nucci, G.pt_BR
dc.contributor.authorWithrington, P.G.pt_BR
unicamp.authorState Univ Campinas, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazil Abbott Labs, Chicago, IL 60612 USA Univ London Queen Mary & Westfield Coll, London E1 4NS, England Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazilpt_BR
dc.subjectEtanolpt_BR
dc.subjectReceptores de endotelinapt_BR
dc.subject.otherlanguageEthanolpt_BR
dc.subject.otherlanguageReceptors, Endothelinpt_BR
dc.description.abstractEthanol can affect the regulation of liver hemodynamics through the release of vasoactive mediators such as nitric oxide and endothelins (ETs). The purpose of this study was to investigate the effects of ethanol on the changes in arterial and portal perfusion pressure induced by ET receptor activation. Ethanol significantly reduced portal, but not arterial perfusion pressure. ET-1 and norepinephrine (used as an ET receptor-independent vasoconstrictor) induced changes in hepatic arterial or portal inflow resistance that were not affected by ethanol treatment. However, an IRL 1620-induced increase in portal, but not arterial, inflow resistance was significantly reduced in ethanol-perfused preparations, an effect observed after either intra-arterial or intraportal administration of the agonist. These results suggest that ethanol can diminish the responsiveness of the portal vascular bed of the canine liver to ETB receptor activationpt
dc.description.eventLippincott Williams & Wilkinspt_BR
dc.relation.ispartofJournal Of Cardiovascular Pharmacologypt_BR
dc.relation.ispartofabbreviationJ. Cardiovasc. Pharmacol.pt_BR
dc.publisher.cityPhiladelphiapt_BR
dc.publisher.countryEUApt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued1998pt_BR
dc.date.monthofcirculationJan.pt_BR
dc.identifier.citationJournal Of Cardiovascular Pharmacology. Lippincott Williams & Wilkins, v. 31, n. S284, n. S286, 1998.pt_BR
dc.language.isoengpt_BR
dc.description.volume31pt_BR
dc.description.issuesupplement1pt_BR
dc.description.firstpageS284pt_BR
dc.description.lastpageS286pt_BR
dc.rightsfechadopt_BR
dc.sourcePUBMEDpt_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0160-2446pt_BR
dc.identifier.wosidWOS:000174051600079pt_BR
dc.identifier.urlhttps://insights.ovid.com/pubmed?pmid=9595460pt_BR
dc.description.sponsorshipFAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorshipCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1FAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.date.available2014-07-30T17:27:44Z
dc.date.available2015-11-26T16:42:55Z-
dc.date.accessioned2014-07-30T17:27:44Z
dc.date.accessioned2015-11-26T16:42:55Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T17:27:44Z (GMT). No. of bitstreams: 0 Previous issue date: 1998en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:42:55Z (GMT). No. of bitstreams: 0 Previous issue date: 1998en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65676
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65676-
dc.description.conferencedateEstados Unidospt_BR
dc.description.conferencelocationJournal of cardiovascular pharmacologypt_BR
dc.description.conferencelocalJ. cardiovasc. pharmacol.pt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source9595460-
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.type.formArtigo original-
dc.description.eventsponsorPhiladelphia, PApt_BR
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