Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65664
Type: Artigo de periódico
Title: Estrogen and alendronate therapies may prevent the influence of estrogen deficiency on the tooth-supporting alveolar bone: a histometric study in rats
Author: Duarte, PM
Goncalves, P
Casati, MZ
de Toledo, S
Sallum, EA
Nociti, FH
Abstract: Background and Objective: The aim of this study was to evaluate histometrically the influence of estrogen deficiency, and its therapies, on the quality of the tooth-supporting alveolar bone. Material and Methods: Seventy-three female rats were randomly assigned to one of the following groups: group 1 (n = 15), sham surgery; group 2 (n = 15), bilateral ovariectomy (OVX); group 3 (n = 14), OVX plus calcitonin (16 IU/kg); group 4 (n = 14), OVX plus estrogen (20 mu g/kg); and group 5 (n = 15), OVX plus alendronate (5 mg/kg). Eighty days after surgery, the animals were killed and their mandibles were removed and processed for histology. Bone density (BD) in the furcation area of the first mandibular molar (i.e. the percentage of demineralized bone tissue in a 1,000 mu m zone under the furcation) was histometrically obtained. Results: Data analysis demonstrated that estrogen deficiency negatively affected the tooth-supporting bone density (79.45% +/- 4.22 and 55.23% +/- 6.45, for groups 1 and 2, respectively), and that estradiol and alendronate therapies prevented this effect (61.67% +/- 6.87, 78.09% +/- 3.12 and 81.47% +/- 4.58, for groups 3, 4 and 5, respectively). Conclusion: Within the limits of this study, it can be concluded that the density of tooth-supporting bone is affected by estrogen deficiency, and that estradiol and alendronate therapies, but not calcitonin, provide protection against this effect.
Subject: alveolar bone
bisphosphonate
calcitonin
osteoporosis
Country: Inglaterra
Editor: Blackwell Publishing
Rights: fechado
Identifier DOI: 10.1111/j.1600-0765.2006.00903.x
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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