Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65603
Type: Artigo de periódico
Title: Essential oils from Baccharis species (Asteraceae) have anti-inflammatory effects for human cells
Author: Florao, A
Budel, JM
Duarte, MD
Marcondes, A
Rodrigues, RAF
Rodrigues, MVN
Santos, CAD
Weffort-Santos, AM
Abstract: Constituents of the essential oils from the aerial parts of Baccharis articulata (Ba), Baccharis genistelloides subsp. crispa (Bc), Baccharis dracunculifolia (Bd) and Baccharis gaudichaudiana (Bg), Asteraceae, obtained by hydrodistil-lation and analyzed by gas chromatography (GC)/mass spectrometry (MS) and GC/flame ionization detector (FID) were identified. Also, their anti-inflammatory potential, focusing their immunomodulatory activity using flow cyto-metric analyses and AgNOR profiles, and anti-chemotactic properties, conducted using a Boyden's chamber system, were investigated. Fifty-eight compounds were characterized, representing 66.7% of the total components detected. The major constituents identified were spathulenol (in Ba, Bd and Bg), tau-gurjunene (in Bg) and palustrol (in Ba). The data presented herein showed that the Baccharis essential oils included in this study were inert for human resting lymphocytes, while all but Ba's inhibited significantly the proliferation of their phytohemagglutinin-stimulated counterparts. In addition, only the essential oil of Bd inhibited significantly the casein-induced human granulocyte chemotaxis. This is the first report concerning the potential diversity of anti-inflammatory activities of the essential oils of Baccharis plants on human cells responsible for the host defense mechanisms that may be of benefit in intervening with immune disorders associated or not with inflammatory conditions.
Subject: Baccharis
Asteraceae
essential oil composition
spathulenol
immunomodulation
chemotaxis
Country: EUA
Editor: Taylor & Francis Inc
Rights: fechado
Identifier DOI: 10.1080/10412905.2012.728081
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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