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Type: Artigo de periódico
Title: Electroanalytical performance of self-assembled monolayer gold electrode for chloramphenicol determination
Author: Codognoto, L
Winter, E
Doretto, KM
Monteiro, GB
Rath, S
Abstract: Monolayers of 2-mercapto-5-methylbenzimidazole (MMB) were prepared on a polycrystalline gold electrode via a self-assembly process to produce a self-assembled monolayer. The resulting electrode was investigated by cyclic voltammetry and electrochemical impedance spectroscopy, and applied to the determination of chloramphenicol (CAP) in a pharmaceutical formulation using flow injection analysis along with amperometric detection. The amperometric cell was operated at -0.75 V (vs Ag/AgCl) at a flow rate of 3 mL min(-1). The method was applied to the determination of CAP in ophthalmic solutions, and its performance was compared to a previously validated HPLC method. The response to CAP is linear in the range from 0.050 to 1.000 A mu mol L(-1) (r = 0.9990), and the limit of detection is 44 A mu mol L(-1).
Subject: Self-assembled monolayer
Gold electrode
Country: Austria
Editor: Springer Wien
Citation: Microchimica Acta. Springer Wien, v. 169, n. 41732, n. 345, n. 351, 2010.
Rights: fechado
Identifier DOI: 10.1007/s00604-010-0339-8
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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